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Background: Neonatal sepsis is a major cause of morbidity and mortality worldwide. Now a days, neonatal sepsis due to Burkholderia cepacia is on rise. This study was conducted to delineate clinical presentation and antibiotic sensitivity pattern from blood culture proven Burkholderia sepsis. Methods: In this retrospective analytical study, thirty-six neonates admitted to Neonatal Intensive Care Unit of a tertiary care hospital with blood culture proven Burkholderia sepsis were included. Clinical manifestation, laboratory findings and antibiotic sensitivity patterns of blood culture proven Burkholderia sepsis were analyzed.Results: : All neonates were inborn and were admitted within 24 hours of birth. Difficulty in breathing was most common presenting symptom and seizure was second in number. There was no association with mode of delivery. Male to female ratio is 1.4:1. Progressive thrombocytopenia was the most consistent feature and in 6 patients also associated with anaemia. Average hospital stay was increased and more in preterm neonates. In this setup piperacillin + tazobactem was found to be most sensitive against Burkholderia cepacia and cotrimoxazole was 2nd in sensitivity.Conclusions: Proper and timely identification of Non Fermentative Gram Negative Bacilli (NFGNB) other than Pseudomonas can help confine morbidity due to such infections. High degree of suspicion helps in early recognition. Efficient housekeeping is necessary to prevent nosocomial infections due to these pathogens.
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Background: Congenital B-cell Acute lymphoblastic leukemia (ALL) is a rare malignancy.Case Characteristics: A newborn infant presented with purpuric spots and ecchymoticpatches, blueberry muffin rash, depressed neonatal reflexes, respiratory distress andhepatosplenomegaly. Peripheral smear revealed atypical blast cells. Serum ELISA waspositive for Rubella IgM and IgG antibodies. Flow cytometry suggested congenital B-cellALL. Outcome: The baby died after 3 days due to suspected intracranial hemorrhage.Message: Congenital leukemia may be rarely associated with congenital rubella infection.
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Background: The knowledge of pulmonary function tests (PFTs) is a basic requirement to understand the respiratory physiology for all medical physiologists and clinicians Pulmonary Function Tests provide objective evidence of nature and severity of lung disease. Objective: To observe FEV1, FVC, FEV1/FVC ratio in healthy male and female school children from 7-14 years of age in Western Rajasthan and to find out the relationship of FEV1, FVC, FEV1/FVC ratio with their height, weight, BSA and sex Methods: The present study was carried out on 112 male and 76 female children of 7-14 years. For Pulmonary Function Tests, FEV1, FVC and FEV1/FVC along with anthropometric data of each subject was recorded.. Data were analyzed by unpaired t test, Pearson correlation coefficient test, simple and multiple regression analysis. Results: FVC and FEV1 values were found significantly (p<0.001) higher in male than those of female. Significant positive correlation of FVC and FEV1 whereas non significant negative correlation of FEV1/FVC were observed with age, height, weight, body surface area in all children. Conclusion: As the weight, age, height and BSA of subjects increases, FEV1 and FVC increases while FEV1/FVC ratio decreases in both the sexes.
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The aim of this study is to find the effect of starch and guar gum 4000 on disintegrating time and dissolution behavior of drug Zolmitriptan from fast dissolving tablet [FDT]. The FDT was prepared by direct compression method. The precompression parameters were evaluated with subjected to angle of repose, bulk and tapped density, hausnefs ratio and Carr's index and all were within limit. The prepared tablets were evaluated for thickness, uniformity of content, hardness, friability, wetting time and in vitro disintegration time and in vivo release of drug. The in vitro release and assay of drug was performance by UV spectrophotometer. The in vivo study reveals that when guar gum [5%] and starch [10%] were used in formulation, the plasma concentration of drug was increased because, it disintegrate tablet rapidly and drug was released rapidly from dosage form and reach quickly in to systemic circulation resultant bioavailability is increased